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In a phenylketonuria mouse model, dual AAV-mediated delivery of an intein-split Staphylococcus aureus KKH-CBE3 achieved approximately 23% on-target correction of the disease-causing Pahenu2 mutation, reversing the disease phenotype without detectable transcriptome-wide or genome-wide off-target mutations [246, 247]

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However, most dermatological organisations including the American Academy of Dermatology and the Philippine Dermatological Society, which has monitored this trend closely given its popularity in Asia note that the long-term safety of high-dose glutathione supplementation specifically for cosmetic skin lightening has not been established

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