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GSK-3 acts upstream of fyn kinase in regulation of nuclear export and degradation of NF-E2 related factor 2

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Recently, our group studied the effect of low dose sodium selenite supplementation (multiple intraperitoneal injection of 4 g/kg body weight) on the 30-day survival of mice against the lethal dose (8 Gy) of WBI with -rays (Table 2) [50]

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Metronomic chemoendocrine treatment resulted in elevated levels of autophagy- and apoptosis-related markers, which correlated with clinical response

This critical regimen serves a dual purpose: it eradicates the circulating malignancy and intentionally disables the patients existing immune system to prevent it from attacking the incoming donor cells