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Metformins Multiple Tissue-Specific Effects Through the Modulation of Autophagy Metformin primarily modulates autophagy to produce tissue-specific effects affecting various physiological and pathological conditions

Therefore, delivery efficiency and formulation design play a critical role in optimizing results

NAFLD/MASLD is increasingly recognized as a metabolically driven inflammatory disorder in which cytokine production arises from both hepatic and extra-hepatic sources

This folate deficiency has been shown to be associated with mitochondrial DNA deletions resulting in reduced mitochondrial function, disruption of neurotransmitter synthesis caused by reduced methyl groups, and decreased proliferative function of regenerative cells in the brain due to impaired nucleotide synthesis 33

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-Ketoglutarate alleviates osteoarthritis by inhibiting ferroptosis via the ETV4/SLC7A11/GPX4 signaling pathway