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Tyrosol (E) (-5.9 kcal/mol) only forms a single hydrogen bond with SER283, while its solvent-exposed position and lack of interaction in the image explain the high RMSD value (~ 3.5 )

Mechanism of cytotoxicity of anticancer platinum drugs: evidence that cis-diamminedichloroplatinum(II) and cis-diammine-(1,1-cyclobutanedicarboxylato)platinum(II) differ only in the kinetics of their interaction with DNA

Recently, both the FDA and the United States National Heart, Lung and Blood Institutes (NHLBI) have underscored the limitations of these measurements 7

Consistent with previous studies in mice, we also observed an increase in branched-chain amino acids (Leucine, Isoleucine, and Valine) in the brains of both DL and CR-fed female mice 12,83

And previous studies in our laboratory have shown that conversion of Cys residues into Sec residues in GPx1 and GPx4 could result in dramatic loss of the catalytic activity 15,16