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Following HMGB1 inhibition or 5-HT7R knockout, the downstream Nrf2/xCT/GPX4 signaling pathways was upregulated, resulting in alleviated depressive-like behaviors (Du et al., 2025)

A study with an endoplasmic reticulum-associated protein (RTN1, Reticulon-1) focused on the inhibition of histone deacetylase (HDAC) enzymes has shown that the protein exhibits inhibitory activity only in the form of a copper complex (Nepravishta et al., 2009[324])

Pancreas 1995

Alongside traditional therapies, these diseases have attracted interest for their potential to be treated with natural bioactive substances that have fewer toxic side effects

Transcriptional insights into the CD8(+) T cell response to infection and memory T cell formation

Allele-specific reprogramming of cancer metabolism by the long non-coding RNA CCAT2