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With respect to the substantial similarity criteria, the applicant asserted that VEST is not substantially similar to other currently available technologies because there is no other technology with a similar mechanism of action with which VEST can be compared, and that therefore, the technology meets the newness criterion

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The irradiated mice were injected daily with SHED-CM, Fibro-CM, or DMEM (10 L/g) into the tail vein immediately after irradiation

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Harnessing mechanisms that regulate the cellular redox state, rather than the redox molecules themselves, might be more effective in the future

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