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Biochemical basis for deficient paracetamol glucuronidation in cats: an interspecies comparison of enzyme constraint in liver microsomes

Using 13 C 1,2 -glucose, we traced the flow of glucose-derived carbon through glycolysis and into the TCA cycle

Initially, the IU/JAX/PITT group created mice that are double homozygous for APOE4 and Trem2 R47H (termed LOAD1) ( APOE4 is the greatest genetic risk factor for LOAD which is thought to increase the risk for AD through both gain and loss of function effects on multiple processes in the brain including amyloid clearance, synaptic plasticity, and cerebrovascular health ( TREM2 R47H is a rare coding mutation with a partial loss of function that alters the behavior of microglia ( via CRISPR/CAS9

doi: 10.1021/acsami.9b09784 136 WilhelmSMAdnaneLNewellPVillanuevaALlovetJMLynchM

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