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The protein expression of ROCK1 and ROCK2 were significantly higher in hypertension-associated ED rats than that in the normal control rats, with a reduction of endothelial NOS, cGMP, and an elevation of norepinephrine-induced hyper-contractions, and acetylcholine-induced hypo-relaxations in the penile tissue [118]

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Current scientific evidence suggests that the high level of genetic variation and rapid selection response required for genetic adaptation is likely limited in many amphibian and reptile populations

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