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doi: 10.1111/jocd.13713

While sulphites dont trigger an allergic (IgE-mediated) reaction, they can cause non-allergic hypersensitivity responses leading to asthma-like symptoms, digestive upset, or headaches (PMID: 1576344)

doi: 10.3892/ijmm.2015.2356 146 ShrivastavaPVaibhavKTabassumRKhanAIshratTKhanMMet al

There have also been rare reports of patients developing viral colitis (cytomegalovirus and herpes simplex virus) while on immunosuppressive medications