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Abbas H, Sayed NSE, Youssef N, Mousa PMEG, Fayez MR, Elsheikh AMMA

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Consistent with our previous results of 4T1 tumor sections, we found that groups treated with CCPCA could deplete GSH, resulting in small tumor area, low positive area ratio, and positive area density of anti-GSH FL signals in U87MG tumors (Fig

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(38) confirmed through in vitro experiments that Rg1 significantly increases the phosphorylation levels of PI3K and Akt, upregulates the anti-apoptotic protein Bcl-2, and inhibits the activity of Bad and caspase-3, thereby preventing hippocampal neuronal degeneration

Future studies will focus on comprehensive toxicology, long-term dosing regimens, and scaling up the manufacturing process to meet Good Manufacturing Practice (GMP) standards, which are critical steps toward human trials