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Reports that neurotoxic aldehydes, which are normally rapidly metabolized by aldehyde dehydrogenase in the brain, accumulate in parkinsonian substantia nigra because aldehyde dehydrogenase gene expression is significantly reduced

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Metabolic Syndrome: This cluster of conditions, including high blood pressure, insulin resistance, and excess belly fat, is often accompanied by elevated GGT

Release of the payload occurs mainly in the lysosome after internalization of the ADC and degradation of both the antibody and linker

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