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however, the two spindles failed to align and come into close apposition to form a compound barrel-shaped structure, producing 2-cell embryos with one or two binucleated blastomeres, which provides a potential rationale for the multinucleated blastomere formation observed in human IVF-derived embryos 22

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revealed that erastin could directly combine with VDAC2/3 to reduce the oxidation rate of NADH, and induce cell ferroptosis (Yagoda et al., 2007)