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Deferasirox nephrotoxicity can be more common in the elderly

Frontiers in Pharmacology , 15

Interestingly, in vivo studies have shown that serum alkaline phosphatase levels are higher in young children (29 days to 1 year, 50 th percentile: males = 218.19, females = 210.62 U/L) compared to older children (17 to 18 years, 50 th percentile: males = 104.74, females = 75.50 U/L) (25), further supporting the enzyme's relevance during early life when the gut barrier is still developing

Vascular dysfunction in diabetes is associated with activation of protein kinase C and enhanced production of glycolytic intermediates, advanced glycation end-products, and reactive oxygen species because of increased glucose metabolism [41]