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It is typically characterized by the presence of circulating autoantibodies that bind to and stimulate the thyroid hormone receptor (TSHR), resulting in hyperthyroidism and goiter

4 The metabolism of coagulation factors can be reduced in the hypothyroid state, requiring increased doses

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Beyond its central mitochondrial-mediated effects, Ashwagandhas anticancer activity is further enhanced through multiple mechanisms, including inhibition of angiogenesis, suppression of metastasis, induction of cell cycle arrest, disruption of mitosis via Withanones interaction with the TPX2-Aurora A complex, and impairment of cellular energy metabolism through inhibition of succinate dehydrogenase [94, 98, 219, 220]

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Proteinprotein interaction network prediction for SlGST proteins As SlGST transcripts and proteomes showed high-stress responsiveness (Fig 7), SlGST proteins might interact with other proteins to modulate the effects of stress