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Individuals with severe liver disease (such as cirrhosis or hepatic encephalopathy) or severe kidney disease should not take L-Glutamine, as their organs may be unable to effectively clear the resulting ammonia, leading to dangerous neurotoxicity

The dysregulation of lipid metabolism is now known as one of the key drivers of oncogenic processes, a metabolic phenotype shown to promote cancer development and therapeutic resistance in various cancers, including CRC (66)

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Increasing disease severity was also found in one study to be associated with decreasing relative abundance of Lactobacillus spp