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In adults, somatomedin alteration contributes to increased osteoclast activity, resulting in weaker bones that are more prone to pathologic fracture and osteoporosis

This essential vitamin supports energy levels and neurological function

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Researchers designing protocols based on this escalation data should reference the published Phase 2 data while monitoring Phase 3 publications for refinements

These findings suggest that targeted inhibition of CD38 ecto-enzymatic activity could be a potential pharmacological approach for SSc fibrosis treatment