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Am J Physiol Lung Cell Mol Physiol 270 , L1031L1039

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Exercise-induced bronchoconstriction does not cause eosinophilic airway inflammation or airway hyperresponsiveness in subjects with asthma

It was originally developed by a major pharmaceutical company and later tested in human trials for digestive recovery after surgery

Crizotinib, a class Ia small molecule dual inhibitor of c-MET and anaplastic lymphoma kinase (ALK) had been proposed for advanced non-small cell lung cancer therapy with activation of either c-ros oncogene 1 (ROS-1) or ALK [110]

The allocation of subjects to the three study arms and study design is shown in the CONSORT diagram (Figure 1)