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158 The common side effects of naltrexone include insomnia, anxiety, dizziness, fatigue and somnolence, headache, nausea, vomiting, constipation, anorexia, abdominal pain, and myalgia

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Although direct evidence of diminished inhibitory phosphorylation at Ser9 in obese WAT has been limited, our findings demonstrate that adipocyte-specific deletion of Ssu72 significantly increases GSK3 phosphorylation at Ser9 under HFD conditions, suggesting that Ssu72 is integral to driving maladaptive changes by maintaining GSK3 in its active, dephosphorylated state, resembling the regulatory mechanism reported for Dyrk1A [68]

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