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In addition, the transmembrane domains of IR and IGF1R may also contribute to some of the signalling differences in our chimeric receptor system, since transmembrane domains of receptor tyrosine kinases, especially IR, have been shown to play an important role in signal propagation in response to ligand binding 46

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GP-S: Writing review & editing, Supervision, Project administration, Conceptualization, Writing original draft

Metab Brain Dis 30:925933 Deon M, Landgraf SS, Lamberty JF, Moura DJ, Saffi J, Wajner M, Vargas CR (2015b) Protective effect of L-carnitine on phenylalanine-induced DNA damage

[PubMed: 2566942] 503

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