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The cellular consequences of IF/aggregate proportion changes are not clear, and the question as to whether these structures correspond to an aggresome uncoating step 54,55 prior to content degradation via autophagy remains to be addressed

Updates on Genes and Genetic Mechanisms Implicated in Primary Angle-Closure Glaucoma

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Covalent/irreversible inhibitors target the redox/catalytic apparatus of TGR with almost no recognition elements that give affinity and selectivity for TGR over off-targets and the cellular redox apparatus resulting in undesirable cross-reactions and low specificity in vivo 25

Furthermore, participants with higher blood glucose levels before the trial experienced greater reductions in after-meal glucose levels (AKAY 2017)

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