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(2) Dual blockade of the NF-B/AP-1 signaling axis via inhibition of IKK phosphorylation (IC50 = 5.8 M) to reduce NF-B nuclear translocation, coupled with suppression of JNK/ERK phosphorylation (EC50 = 7.2 M) to impede c-Jun/Fos complex formation, thereby synergistically downregulating MMP-1/3/9 transcription (Hwang et al., 2013