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Endogenous glucocorticoids regulate the circadian expression of a number of inflammatory cytokines through binding to the intracellular GR, which suppresses the expression of inflammatory mediators by interacting with GREs and by directly regulating transcription factors such as NF-B, Activator protein-1 (AP-1) as transrepression 59 (Fig

Ibrahim SS, Barakat M, Helmy H (2011) Role of selenium in attenuating cardiac and hepatic damages induced by the antitumor agent, doxorubicin

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It manifests itself clinically with headaches, visual disturbances and hormonal insufficiency of the pituitary gland (60)