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Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN

This discovery paved the way for the identification of potential therapeutic targets and resistance markers that could significantly contribute to the treatment of breast cancer [17, 18]

Neutrophil-mediated inflammatory responses are considered to play key roles in COPD pathogenesis ( Currently, COPD treatment mainly includes bronchodilators, inhaled corticosteroids, and phosphodiesterase-4 inhibitors, but these therapeutic approaches have relatively limited effects on neutrophil-mediated inflammation (Wedzicha et al., 2016)

doi: 10.1089/jir.2014.0210

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Fifty eight patients, clinically diagnosed as having chronic gastritis (median age 45 y