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S.typhimurium Ames tester strains have rfa mutations that allow for better permeability of the outer membrane, which was examined for sensitivity to crystal violet (CASRN 54862-9, MW = 408) [19]

doi:10.1589/jpts.27.1781

This patient-specific requirement creates the fundamental limitation of the 503A model: scalability

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Interferon- mediates human beta cell HLA class I overexpression, endoplasmic reticulum stress and apoptosis, three hallmarks of early human type 1 diabetes