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Selenium and resveratrol attenuated diabetes mellitus-mediated oxidative retinopathy and apoptosis via the modulation of TRPM2 activity in mice

PLoS One 8:e74522

What they found (summary): NAD+ is the integrator of metabolic and stress signals The decline in NAD+ with age is a causal factor , not merely a correlation PARP and CD38 are the main consumers of NAD+ in aging cells Selective CD38 inhibitors are a new therapeutic option NAD+ has potential in neurodegeneration (Alzheimers, Parkinsons, ALS) Why it matters: Verdins review in Science gave the NAD+ field academic prestige

While the initial effects can be noticed within 48 to 72 hours, it might take several weeks to experience the full benefits

This is equivalent to about 7 standard drinks for men and 5 standard drinks for women

The first five subjects who volunteered for the histological evaluation underwent pre- and post-treatment biopsies