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Modeling enterohepatic circulation

In addition, artemisinin increases ROS levels, and FIN56 binds and activates squalene synthase to accumulate ROS (Kang et al., 2019), leading to the depletion of endogenous antioxidant CoQ10 and then inducing ferroptosis by lipid peroxidation

In the circulation, iron is bound to transferrin (about 3 mg), which safely transports it to the bone marrow for haemoglobin synthesis

Data availability Some data generated or analyzed during this study are included in supplementary information files

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