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This finding is consistent with earlier studies stating that decreases in cytosolic Ca 2+ can induce autophagy 29

Sample collection In October of 2011, our research group comprised of Democratic Republic of the Congo (DRC)-based physicians and experts on konzo along with research scientists collected 60 plasma samples from children affected with konzo and those who were unrelated and unaffected in Kahemba, DRC

doi:10.1097/GOX.0000000000005860 73

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72 Significant differentially expressed genes between conditions were identified by DESeq2 with a Benjamini-Hochberg adjusted p-value 0.5