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[DOI] [PMC free article] [PubMed] [Google Scholar] 161.George S, et al

Front Pharmacol:1590 Irving GR, Howells LM, Sale S, Kralj-Hans I, Atkin WS, Clark SK, Britton RG, Jones DJ, Scott EN, Berry DP, Hemingway D (2013) Prolonged biologically active colonic tissue levels of curcumin achieved after oral administrationa clinical pilot study including assessment of patient acceptability

In contrast, synthetic, proliferative VSMCswhich dominate pathologies such as atherosclerosisundergo a metabolic shift toward glycolysis and possess reduced antioxidant defenses, rendering them highly vulnerable to cuproptosis [154, 155]

But it must be acknowledged that, like heavy metals, excessive concentrations of metal ions from the aforementioned metals can induce various forms of cellular damage and apoptosis, resulting in increased wound inflammation and oxidative stress responses (Song et al., 2019)