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It is conceivable that to design an MB vaccine potentially functional in any patient independently of the molecular subgroup and stage of development, a good immunogenic antigen should be identified

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In these patients, the excess of dietary methionine might even reduce their hyperhomocysteinemia by favoring homocysteine catabolism (Loehrer et al, 1996)

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Future success hinges on identifying CRC-enriched antigens, particularly on TME components (CAFs, CSCs) and leveraging payloads with robust bystander effects to overcome spatial heterogeneity (103)