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Interventions that improve phospholipid asymmetry by modulating flippase or scramblase activity potentially aided by antioxidants like ascorbate may inhibit premature phosphatidylserine exposure, postpone pathological clearance, and mitigate vascular obstruction in thalassemia and sickle cell anemia (80)

In 2021, Kishimoto et al., in a double-blind, placebo-controlled clinical trial, evaluated the anti-inflammatory effects of curcuRouge for 4 weeks on systemic inflammation in adults over 60 years of age in Japan [62]

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Mouse primary hepatocytes were isolated and cultured using the following method: liver tissue was digested with collagenase type II (Gibco) to separate the hepatocytes [20, 21]

High-resolution approaches, including super-resolution microscopy, electron tomography, and emerging ovarian three-dimensional imaging techniques, can be applied to age-stratified ovarian samples to quantitatively map changes in mitochondria-ER, mitochondria-lysosome, mitochondria-peroxisome, and mitochondria-lipid droplet contact sites in oocytes and granulosa cells