Effect of metformin on bile salt circulation and intestinal motility in type 2 diabetes mellitus
DOI: 10.1210/endo.134.5.8156994 Arvat E et al
Standard AOD-9604 Dosing Protocol Typical Dosing Range: Standard Dose: 250-500 mcg per day Clinical Trial Dose: 1 mg (1,000 mcg) per day (most effective in studies) Conservative Start: 250 mcg per day for first week Maintenance Range: 500 mcg per day for sustained protocols Frequency: Once daily, typically before breakfast Timing Rationale: Morning fasted state maximizes fat oxidation potential Cycle Length: 12-24 weeks for body composition protocols Administration Route: Subcutaneous injection (abdomen, thigh, or upper arm) Reconstitution: Bacteriostatic water, standard peptide protocols Note: Clinical trials used oral formulations, but subcutaneous administration is more common in current use due to improved bioavailability
Opinion Biotechnology 24 (2), 160168
The loading phase requires 4mg to 5mg weekly for the first month, which represents a meaningful investment
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