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a minority of patients respond clinically to oral therapy

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Certainly, early life stressful events such as maternal separation in the rodent, or child abuse/loss of a parent in humans can cause disruption of the HPA axis in this way ( In addition to, or perhaps as a result of, disrupting the HPA axis, the parental influence at this time is also crucial for establishing feeding patterns long-term

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Expression and activation of matrix metalloproteinases in wounds: modulation by the tripeptide-copper complex glycyl-l-histidyl-l-lysine-Cu2+

However, as a secondary analysis the authors correlated their findings to a previous study (Mller-Levet et al., 2013) to identify potential genes with altered expression and DNA methylation changes following sleep deprivation