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Using selected doses and time point for ASA toxicity, we have demonstrated that when GSH synthesis is inhibited in HepG2 cells by buthionine sulfoximine (BSO), prior to ASA treatment, cytotoxicity of the drug is augmented

J Clin Endocrinol Metab 105(12) 2020 PMC7566388 Olson KL, Neiberg RH, Espeland MA, Johnson KC, Knowler WC, Pi-Sunyer X, Staiano AE, Wagenknecht LE, Wing RR, Look AHEAD Research Group

[i] This particular peptide may be found in the bloodstreams of animals naturally, and it has been hypothesized as a potential component in controlling the proliferation, development, and death of vascular endothelial cells

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We acknowledge the critical support from the Youth Innovation Promotion Association of Guangzhou Institutes of Biomedicine and Health and the BSL-3 laboratory team at the Wuhan Institute of Virology

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