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10.1096/fj.07-8218com 2 Al-AlawiM.HassanT.ChotirmallS

Targeting of HIF-alpha to the von hippel-lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

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Previous work from the Weinberg Lab had shown that inflammation in organ tissue can provoke dormant breast cancer cells to start growing again

Locations and Appointments Transplantation & Cellular Therapy Center 610 Second Avenue, 2nd Floor, New York, NY 10016 Phone Fax 929-455-9087 Perlmutter Cancer Center38th Street 240 East 38th Street, 19th Floor, New York, NY 10016 Phone Fax 929-455-9087 Research My Research Interests AML, MPD, STAT3, targeted treatments, multiple myeloma, acute myeloid leukemia, myeloproliferative disorder, signal transducer and activator of transcription protein 3 Research Summary STAT3 contributes to several aspects of the malignant phenotype, including increased cell survival and proliferation and decreased host anti-tumor immunity in the tumor microenvironment

Ye J, Kumanova M, Hart LS, Sloane K, Zhang H, De Panis DN, Bobrovnikova-Marjon E, Diehl JA, Ron D, Koumenis C (2010) The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation