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In contrast to non- APOE4 carriers, elevated ketone body levels do not show cognitive benefits in APOE4 carriers indicating that APOE4 might impact the transport of ketone bodies executed by MCTs or the metabolism of ketone bodies in the mitochondria [100, 101]

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The genotypes found near the biplot origin were bad performers compared to the distant ones

While the mechanism was not investigated in this clinical study, prior preclinical studies have identified -caryophyllene, a major constituent of Piper nigrum , as a selective cannabinoid receptor 2 (CB2) agonist, suggesting that endocannabinoid modulation may contribute to analgesic effects [149]