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4.2.4 Allosteric inhibitors Allosteric inhibitors represent a class of inhibitors that do not compete for the SAM or NAM binding sites on NNMT

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[3] For confirmed deficiency with neurological involvement: 1 mg IM on alternate days until no further improvement, then 1 mg every two months urgent initiation is essential to prevent irreversible nerve damage

NSAIDs may slightly reduce the inflammatory component of healing, but this is usually not clinically significant

Future studies will be needed to elucidate the role of these metabolites in the behavioural anomalies in the 22q11.2DS mouse models