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Description

when people reach age 40, they produce around 30% less glutathione, and by age 65, that reduction can reach 50%

No MDH activity was observed by Ca 2+ addition (Figure 10C)

Key findings revealed that certain TCA cycle enzymes, such as succinate dehydrogenase (SDH) and fumarate hydratase (FH), act as tumor suppressors, establishing direct links between mitochondrial dysfunction and tumorigenesis