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Potentially deleterious reactive oxygen species (ie, superoxides, peroxides, and hydroxyl radicals) are produced during the oxidation of fuels (oxidative phosphorylation) in mitochondria as byproducts of the utilization of molecular oxygen in the electron transport chain

Excretion is presumed to occur primarily through renal and hepatic routes, based on typical peptide pharmacokinetics

However, overexpression of -syn interferes with this process

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Thus, TAMs promote tumor growth and metastasis and promote the generation of new blood vessels (i.e., angiogenesis) via an activated wound healing (i.e., anti-inflammatory) pathway that provides nutrients and growth signals for proliferation and invasion

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