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The vast majority of these microbes inhabits the human gastrointestinal (GI) tract and display an intricate ecosystem of Bacteria, Archaea, and Eukarya, that plays an important role in the maintenance of physiological homeostasis, through the regulation of immunity, the metabolism of nutrients, and the protection against the pathogenic invasion

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Numerous physiological and metabolic processes in both plants and animals require essential trace elements

Children, especially those younger than six years of age

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have shown that patients with septic shock who are admitted to the ICU ( N = 18) have a significantly higher median expression of syndecan-1 than healthy individuals (111)