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Description

Early-life stress and inflammation: a systematic review of a key experimental approach in rodents

Chaihu Shugan San (CSS), first documented in the Ming Dynastys Jingyue Quanshu, is a classical formula in traditional Chinese medicine

The aims were to (i) evaluate the effects of a single low dose (2 g) of a well-characterized kratom product on the pharmacokinetics of dextromethorphan and midazolam in healthy adult participants and (ii) advance the mechanistic understanding of the resulting pharmacokinetic kratom-midazolam interaction using physiologically-based pharmacokinetic (PBPK) modeling and simulation