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For other human diseases, including diabetes, the role of oxidative stress on the onset and secondary pathology is not that important (or at least the results are contradictory) (Seet et al., 2010

Specifically, when N-GSDMD forms pores in the cell membrane, the force generated by the concentration gradient expelling potassium ions out of the cell is roughly offset by the electric field force that pulls potassium ions into the cytoplasm, resulting in the passage of potassium ions through the membrane pores

( A and B ) Immunoblot of MRD525 ( A ) and MRD639 ( B ) cells treated with different concentrations (nM) of mTORC1 inhibitors for 4 hours

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