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The relapsing fever spirochete Borrelia hermsii contains multiple, antigen-encoding circular plasmids that are homologous to the cp32 plasmids of Lyme disease spirochetes

As TB-500 appears to be well-tolerated by test subjects while offering a range of potentially beneficial biological effects, researchers interested in conducting long-term research have multiple avenues that they may wish to explore

1 - 13 Illustratively, beneficial activity in heart assay includes counteraction of the doxorubicin cardiomyopathy, 41 distinctive arrhythmias induced by digitalis, 42 hyperkalemia, 43 hypokalemia, 44 succinylcholine, 45 bupivacaine, 46 and neuroleptics

This is because the gut and liver are anatomically linked via the portal system (14)

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There are multiple reports in the clinical literature that indicate the use of antiepileptic drugs during pregnancy results in an increased incidence of congenital malformations in offspring