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Generally, for all oral drugs, they can only be absorbed after being dissolved in the aqueous environment of the gastrointestinal (GI) tract

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Diabetes Care 32 , 14971502 (2009)

The results reported that AngIV had a very short half life of less than 2 minutes, however, each of the N-terminal modified compounds, such as Dihexa, exhibited elongated half-lives in comparison to the parent compound