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Oxidative stress within the TME remains a major obstacle to the efficacy of CAR T-cell and CAR-NK cell therapies against solid tumors [258]

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In a large trial, semaglutide 2.4 mg led to about 14.9% mean body-weight loss at 68 weeks versus 2.4% with placebo

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TMPRSS2, a serine protease expressed in the prostate on the apical surface of luminal epithelial cells and released into semen in prostasomes, is misregulated in prostate cancer cells