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52,53 Enzymes such as protein kinase C (PKC), MAPK, and protein kinase A (PKA) modulate NOX activation, whereas the tumor suppressor p53 regulates both antioxidant and prooxidant responses, promoting ROS production and apoptosis in cancer cells

This superimposition was conducted to reduce the root mean square variances between the corresponding residues in the protein structure, and then corresponding PCs were calculated under default parameters using the Bio3d package 51