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8 Conclusions and future perspectives In summary, CP/CPPS is not merely a simple localized infection, but rather a complex pathological microenvironment interwoven by an immune-inflammatory storm, oxidative stress imbalance, neuroendocrine network dysregulation, and microbial heterogeneity. This microenvironment exerts profound cascading toxic effects on the entire life cycle of spermatozoa, comprehensively covering critical stages from spermatogenesis and epididymal maturation to fertilization and capacitation

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SCLC accounts for 15% of lung cancers and is associated with smoking, including neuroendocrine (NE) and non-neurosecretory (Non-NE) types (129)