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However, no incidence of death was observed in any of these two groups

It was originally isolated in 1977 from the cerebral venous blood of rabbits and has since been found to be present in small amounts in human brains and plasma, with higher concentrations later in the day.3 4 It, or a similar substance, is also present at higher concentrations in human breast milk.5 Because DSIP can cross the blood-brain barrier and is easily absorbed via the gut (unusual for a peptide), some researchers have hypothesized that it may facilitate post-feeding sleep tendencies among newborns, though it remains unclear whether DSIP truly has a hand in neonate sleep-wake cycles.4 5 6 Its mechanism of action is likewise unclear, but it may have something to do with endocrine regulation

Spadaro, D

Asian Pac J Trop Med

Both drugs are being developed by Novo Nordisk, likely reflecting a portfolio strategy: CagriSema as the first-to-market injectable combination, and amycretin as a follow-on oral option for patients who prefer pills