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Accumulation of ethanol-associated reactive molecules, e.g., reactive oxygen (ROS) and nitrogen species (RNS), and electrophilic products, e.g., acetaldehyde and lipid peroxidation-derived products, can be harmful to biological systems due to their propensity to inactivate enzymes, leading to loss of protein function, DNA damage and cell death 4

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Furthermore, nuclear export of genome-derived dsRNA is needed for the interaction with cytoplasmic dsRNA sensors, which can be prevented by degradation by nucleases in the nucleus such as the nuclear RNA exosome and potentially Drosha (188)