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Tirzepatide at its highest dose (15 mg) produced 22.5% weight loss in the SURMOUNT-1 trial (N=2,539) at 72 weeks [8]

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For patients whose levels fall in the borderline or gray zone, a methylmalonic acid (MMA) test provides greater specificity MMA levels rise when B12 is functionally inadequate at the cellular level, even if serum B12 appears borderline normal