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Here we report cryo-electron microscopy (cryo-EM) structures of human OCTN2 in a substrate-free inward-facing conformation, a substrate-bound occluded conformation, and an ipratropium-bound inward-facing conformation, revealing how OCTN2 binds and transports carnitine

The absence of universally accepted reference ranges and calibration standards further complicates cross-study comparisons and limits the translation of these biomarkers into routine clinical practice

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& Sally Woods, Diane Shaw 6 7 Rob Bridges 8 Brad Veloz & Mike Rodriguez 9 10 Carey Spikes 11 Carolyn Mobley &

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Bnip3 mediates the hypoxia-induced inhibition on mammalian target of rapamycin by interacting with Rheb